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cb2r genes  (Revvity)


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    Revvity cb2r genes
    Cb2r Genes, supplied by Revvity, used in various techniques. Bioz Stars score: 90/100, based on 14 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/cb2r+genes/Membrane+Target+Systems%3A+Cannabinoid+CB2+(human)+membrane+preparation/pm29229226-309-13-20
    Average 90 stars, based on 14 article reviews
    cb2r genes - by Bioz Stars, 2026-10
    90/100 stars

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    Related Articles

    Binding Assay:

    Article Title: New pyridazinone-4-carboxamides as new cannabinoid receptor type-2 inverse agonists: Synthesis, pharmacological data and molecular docking
    Article Snippet: Please cite this article as: G. Ragusa, M. Gómez-Cañas, P. Morales, C. Rodríguez-Cueto, M.R.. Pazos, B. Asproni, E. Cichero, P. Fossa, G.A.. Pinna, N. Jagerovic, J. Fernández-Ruiz, G. Murineddu, New pyridazinone-4-carboxamides as new cannabinoid receptor type-2 inverse agonists: Synthesis, pharmacological data and molecular docking, European Journal of Medicinal Chemistry (2017), doi: 10.1016/j.ejmech.2017.01.002.

    Article Title: Novel sulfenamides and sulfonamides based on pyridazinone and pyridazine scaffolds as CB 1 receptor ligand antagonists.
    Article Snippet: A series of sulfenamide and sulfonamide derivatives was synthesized and evaluated for the affinity at CB1 and CB2 receptors.. The N-bornyl-S-(5,6-di-p-tolylpyridazin-3-yl)-sulfenamide, compound 11, displayed good affinity and high selectivity for CB1 receptors (Ki values of 44.6 nM for CB1 receptors and > 40 μM for CB2 receptors, respectively).. The N-isopinocampheylsulfenamide 12 and its sulfonamide analogue 22 showed similar selectivity for CB1 receptors with Ki values of 75.5 and 73.2 nM, respectively.

    Transfection:

    Article Title: New pyridazinone-4-carboxamides as new cannabinoid receptor type-2 inverse agonists: Synthesis, pharmacological data and molecular docking
    Article Snippet: Please cite this article as: G. Ragusa, M. Gómez-Cañas, P. Morales, C. Rodríguez-Cueto, M.R.. Pazos, B. Asproni, E. Cichero, P. Fossa, G.A.. Pinna, N. Jagerovic, J. Fernández-Ruiz, G. Murineddu, New pyridazinone-4-carboxamides as new cannabinoid receptor type-2 inverse agonists: Synthesis, pharmacological data and molecular docking, European Journal of Medicinal Chemistry (2017), doi: 10.1016/j.ejmech.2017.01.002.

    Article Title: Novel sulfenamides and sulfonamides based on pyridazinone and pyridazine scaffolds as CB 1 receptor ligand antagonists.
    Article Snippet: A series of sulfenamide and sulfonamide derivatives was synthesized and evaluated for the affinity at CB1 and CB2 receptors.. The N-bornyl-S-(5,6-di-p-tolylpyridazin-3-yl)-sulfenamide, compound 11, displayed good affinity and high selectivity for CB1 receptors (Ki values of 44.6 nM for CB1 receptors and > 40 μM for CB2 receptors, respectively).. The N-isopinocampheylsulfenamide 12 and its sulfonamide analogue 22 showed similar selectivity for CB1 receptors with Ki values of 75.5 and 73.2 nM, respectively.



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    <t>CB2R</t> protects against LPS-induced shock and proinflammatory cytokines production in mice. (a) CB2R +/+ ( n = 15) and CB2R −/− ( n = 15) mice were challenged with LPS (15 mg/kg, i.p.). Survival was assessed for 24 h. ** P < 0.01. (b)–(d), ELISA detection of serum TNF- α , IL-6 and HMGB1 levels 3 h after LPS (5 mg/kg) challenge in CB2 +/+ ( n = 5) or CB2 −/− ( n = 5) mice. Data are means ± SEM * P < 0.05, and ** P < 0.01. (e) Observation of 72 h survival rate in C57BL/6 mice treated with LPS (30 mg/kg, i.p.) in the absence of presence of indicated doses of GW405833 (i.p.). Mice treated with vehicle as control. n = 15 per group and * P < 0.05 versus vehicle. (f)–(h) ELISA detection of serum TNF- α , IL-6, and HMGB1 levels 6 h after LPS (5 mg/kg, i.p.) challenge in the absence or presence of indicated doses of GW405833 (i.p.). n = 8 in vehicle, n = 5 in 3 mg/kg, n = 10 in 10 mg/kg, data are means ± SEM, and ** P < 0.01 versus vehicle.
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    CB2R protects against LPS-induced shock and proinflammatory cytokines production in mice. (a) CB2R +/+ ( n = 15) and CB2R −/− ( n = 15) mice were challenged with LPS (15 mg/kg, i.p.). Survival was assessed for 24 h. ** P < 0.01. (b)–(d), ELISA detection of serum TNF- α , IL-6 and HMGB1 levels 3 h after LPS (5 mg/kg) challenge in CB2 +/+ ( n = 5) or CB2 −/− ( n = 5) mice. Data are means ± SEM * P < 0.05, and ** P < 0.01. (e) Observation of 72 h survival rate in C57BL/6 mice treated with LPS (30 mg/kg, i.p.) in the absence of presence of indicated doses of GW405833 (i.p.). Mice treated with vehicle as control. n = 15 per group and * P < 0.05 versus vehicle. (f)–(h) ELISA detection of serum TNF- α , IL-6, and HMGB1 levels 6 h after LPS (5 mg/kg, i.p.) challenge in the absence or presence of indicated doses of GW405833 (i.p.). n = 8 in vehicle, n = 5 in 3 mg/kg, n = 10 in 10 mg/kg, data are means ± SEM, and ** P < 0.01 versus vehicle.

    Journal: Mediators of Inflammation

    Article Title: Cannabinoid Receptor 2 Protects against Acute Experimental Sepsis in Mice

    doi: 10.1155/2013/741303

    Figure Lengend Snippet: CB2R protects against LPS-induced shock and proinflammatory cytokines production in mice. (a) CB2R +/+ ( n = 15) and CB2R −/− ( n = 15) mice were challenged with LPS (15 mg/kg, i.p.). Survival was assessed for 24 h. ** P < 0.01. (b)–(d), ELISA detection of serum TNF- α , IL-6 and HMGB1 levels 3 h after LPS (5 mg/kg) challenge in CB2 +/+ ( n = 5) or CB2 −/− ( n = 5) mice. Data are means ± SEM * P < 0.05, and ** P < 0.01. (e) Observation of 72 h survival rate in C57BL/6 mice treated with LPS (30 mg/kg, i.p.) in the absence of presence of indicated doses of GW405833 (i.p.). Mice treated with vehicle as control. n = 15 per group and * P < 0.05 versus vehicle. (f)–(h) ELISA detection of serum TNF- α , IL-6, and HMGB1 levels 6 h after LPS (5 mg/kg, i.p.) challenge in the absence or presence of indicated doses of GW405833 (i.p.). n = 8 in vehicle, n = 5 in 3 mg/kg, n = 10 in 10 mg/kg, data are means ± SEM, and ** P < 0.01 versus vehicle.

    Article Snippet: CB2R gene knockout (CB2R −/− ) mice were purchased from Jackson Laboratory (Bar Harbor, Maine, USA) and expanded under specific pathogen-free conditions in Laboratory Animal Centre of Second Military Medical University.

    Techniques: Enzyme-linked Immunosorbent Assay, Control

    GW405833 inhibits ConA-induced splenocytes proliferation partially via CB2R activation. (a) Splenocytes isolated from CB2R +/+ mice were treated vehicle or ConA (5 μ g/mL) in the absence or presence of GW405833 (1–10 μ M) for 24 h. Splenocytes proliferation was detected by CCK-8. Data are means ± SD ( n = 4) and ** P < 0.01. (b) Splenocytes isolated from CB2R +/+ and CB2R −/− mice were treated with ConA (5 μ g/mL) in the absence or presence of GW405833 (10 μ M) for 24 h. Splenocytes proliferation was detected by CCK-8. Data are means ± SD ( n = 4) and ** P < 0.01.

    Journal: Mediators of Inflammation

    Article Title: Cannabinoid Receptor 2 Protects against Acute Experimental Sepsis in Mice

    doi: 10.1155/2013/741303

    Figure Lengend Snippet: GW405833 inhibits ConA-induced splenocytes proliferation partially via CB2R activation. (a) Splenocytes isolated from CB2R +/+ mice were treated vehicle or ConA (5 μ g/mL) in the absence or presence of GW405833 (1–10 μ M) for 24 h. Splenocytes proliferation was detected by CCK-8. Data are means ± SD ( n = 4) and ** P < 0.01. (b) Splenocytes isolated from CB2R +/+ and CB2R −/− mice were treated with ConA (5 μ g/mL) in the absence or presence of GW405833 (10 μ M) for 24 h. Splenocytes proliferation was detected by CCK-8. Data are means ± SD ( n = 4) and ** P < 0.01.

    Article Snippet: CB2R gene knockout (CB2R −/− ) mice were purchased from Jackson Laboratory (Bar Harbor, Maine, USA) and expanded under specific pathogen-free conditions in Laboratory Animal Centre of Second Military Medical University.

    Techniques: Activation Assay, Isolation, CCK-8 Assay

    CB2R partially mediates the inhibitory effects of GW405833 on ConA-induced TNF- α and IL-6 production in splenocytes. (a)-(b) Splenocytes isolated from CB2R +/+ mice were treated with vehicle or ConA (5 μ g/mL) in the absence or presence of GW405833 (1–10 μ M) for 24 h. The levels of IL-6 and TNF- α in the supernatants were detected by ELISA. Data are means ± SD ( n = 3), * P < 0.05, and ** P < 0.01 versus ConA. (c)-(d) Splenocytes isolated from CB2R +/+ and CB2R −/− mice were treated with ConA (5 μ g/mL) in the absence or presence of GW405833 (10 μ M) for 24 h. The levels of IL-6 and TNF- α in the supernatants were detected by ELISA. Data are means ± SD ( n = 3), * P < 0.05, and ** P < 0.01.

    Journal: Mediators of Inflammation

    Article Title: Cannabinoid Receptor 2 Protects against Acute Experimental Sepsis in Mice

    doi: 10.1155/2013/741303

    Figure Lengend Snippet: CB2R partially mediates the inhibitory effects of GW405833 on ConA-induced TNF- α and IL-6 production in splenocytes. (a)-(b) Splenocytes isolated from CB2R +/+ mice were treated with vehicle or ConA (5 μ g/mL) in the absence or presence of GW405833 (1–10 μ M) for 24 h. The levels of IL-6 and TNF- α in the supernatants were detected by ELISA. Data are means ± SD ( n = 3), * P < 0.05, and ** P < 0.01 versus ConA. (c)-(d) Splenocytes isolated from CB2R +/+ and CB2R −/− mice were treated with ConA (5 μ g/mL) in the absence or presence of GW405833 (10 μ M) for 24 h. The levels of IL-6 and TNF- α in the supernatants were detected by ELISA. Data are means ± SD ( n = 3), * P < 0.05, and ** P < 0.01.

    Article Snippet: CB2R gene knockout (CB2R −/− ) mice were purchased from Jackson Laboratory (Bar Harbor, Maine, USA) and expanded under specific pathogen-free conditions in Laboratory Animal Centre of Second Military Medical University.

    Techniques: Isolation, Enzyme-linked Immunosorbent Assay

    CB2R is critical for the inhibitory role of GW405833 on LPS-triggered IL-6, TNF- α , and HMGB1 production in macrophages. (a)–(c) Peritoneal macrophages isolated from CB2R +/+ mice were treated with vehicle or LPS (1 ng/mL) in the absence or presence of GW405833 (1–10 μ M) for 24 h. The levels of IL-6, TNF- α , and HMGB1 in the supernatants were detected by ELISA. (d)–(f) Peritoneal macrophages isolated from CB2R −/− mice were treated as described in (a)–(c). The levels of IL-6, TNF- α , and HMGB1 in the supernatants were detected by ELISA. Data are means ± SD ( n = 3), * P < 0.05, and ** P < 0.01 versus LPS.

    Journal: Mediators of Inflammation

    Article Title: Cannabinoid Receptor 2 Protects against Acute Experimental Sepsis in Mice

    doi: 10.1155/2013/741303

    Figure Lengend Snippet: CB2R is critical for the inhibitory role of GW405833 on LPS-triggered IL-6, TNF- α , and HMGB1 production in macrophages. (a)–(c) Peritoneal macrophages isolated from CB2R +/+ mice were treated with vehicle or LPS (1 ng/mL) in the absence or presence of GW405833 (1–10 μ M) for 24 h. The levels of IL-6, TNF- α , and HMGB1 in the supernatants were detected by ELISA. (d)–(f) Peritoneal macrophages isolated from CB2R −/− mice were treated as described in (a)–(c). The levels of IL-6, TNF- α , and HMGB1 in the supernatants were detected by ELISA. Data are means ± SD ( n = 3), * P < 0.05, and ** P < 0.01 versus LPS.

    Article Snippet: CB2R gene knockout (CB2R −/− ) mice were purchased from Jackson Laboratory (Bar Harbor, Maine, USA) and expanded under specific pathogen-free conditions in Laboratory Animal Centre of Second Military Medical University.

    Techniques: Isolation, Enzyme-linked Immunosorbent Assay